Radiological Prediction of Response to Neoadjuvant Chemoimmunotherapy for Triple-negative Breast Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-75
SponsorCentre Henri Becquerel

About this trial

The aim of our study is to find the best imaging technique, alone or in combination, that can best predict a complete response (absence of tumour cells). It also seems important to identify blood markers able to predict which patients will benefit most from treatment, with a view to personalising them, or which patients will be most at risk of toxicities, particularly related to immunotherapy, with a view to personalising monitoring.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Signed informed consent

Patient with histologically proven TNBC

Indication for neo-adjuvant chemo-immunotherapy treatment

Age between 18 and 75

Disqualifiers

Pregnant or breast-feeding women

Contraindication to immunotherapy

Inflammatory breast cancer (T4d)

Metastatic patients

Trial design

Design model

Single group

Treatments tested in this trial

  • Imaging assessment

    Other intervention

    The patient will have four imaging exam : Ultrasound, angio/mammography, MRI and PET-scan

Treatment groups

115 Participants
are divided into 1 treatment group
Group A: PRECISION ARMExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

concordance rate between quadrimodal radiological assessment (ultrasound, angiography/mammography, MRI, PET-CT) and histologically-obtained response following neoadjuvant chemo-immunotherapy in patients with triple-negative breast cancer (TNBC).

concordance of the response between radiological assessement and histological response

Time frame
two weeks after surgery

Secondary outcomes

Other outcomes

Sponsors and contacts

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