The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy. By observing parameters such as the size, morphology, scattering intensity, and movement speed of pathogens, combined with the clinical characteristics of patients, a rapid diagnosis of Pseudomonas aeruginosa infection can be made. At the same time, the bronchoalveolar lavage fluid samples of patients infected with Pseudomonas aeruginosa before and after treatment were compared, and the quantity and vitality of Pseudomonas aeruginosa were observed to judge the efficacy of antibiotics.
Aged 18 years and above
After admission, Pseudomonas aeruginosa was cultured in bronchoalveolar lavage fluid or lower respiratory tract aspirates
Age under 18 years old or over 90 years old
Pregnancy, lactation period -
Suspected or diagnosed patients with pulmonary infection caused by Pseudomonas aeruginosa
Cohort
Prospective
bronchoscopy
Procedure/SurgeryWe will perform bronchoscopy and collect bronchoalveolar lavage fluid (BALF)
The size of pathogens
Measure the size of pathogens
scattering intensity of pathogen
Determine the shape of pathogens through scattering intensity
movement speed of pathogens
Measure the movement speed of pathogens, such as flagellates like Pseudomonas aeruginosa, which have a fast movement speed
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