Rapid Research in Diagnostics Development for TB Network

Trial design

Treatments tested in this trial

• Novel mycobacterial culture techniques

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate tests intended to make culture more sensitive, faster, and have less contamination.

• Novel sputum smear microscopy techniques

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate new staining techniques or visualization methods to increase the sensitivity of smear microscopy.

• Sputum-based molecular assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate semi-automated or automated molecular assays intended for use at near point of care or point of care.

• Tongue swab-based molecular assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate semi-automated or automated molecular assays intended for use at near point of care or point of care.

• Urine LAM assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate urine LAM assays incorporating techniques such as analyte concentration, higher sensitivity or specificity antibodies, or enhanced visualization to improve LAM detection.

• Blood-based host immune response assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate assays measuring host immune response parameters intended for use at near point of care or point of care.

• Breath-based assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate assays assessing volatile organic compounds or exhaled breath condensate for near point of care of point of care detection of TB.

• Artificial intelligence-based digital health tools

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate AI-based algorithms evaluating images (chest x-ray, ultrasound) or sounds (cough sounds, lung sounds) including an Infrasound-to-ultrasound e-stethoscope (Level 42 AI, USA).

• Phage-based assays

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate assays using phages to lyse mycobacterial cells for detection of DNA or antigens.

• Cartridge-based molecular assays for detecting drug resistance

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate semi-automated or automated molecular assays intended for use at near point of care or point of care.

• Sequencing-based assays for detecting drug resistance

  Diagnostic test Diagnostic testA test used to detect or assess a condition, such as imaging or a laboratory test.

  We will evaluate targeted and whole genome sequencing assays.