RDW and RV-PA Coupling in Acute PE

ConditionPulmonary Embolism Acute

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorAssiut University

About this trial

Prior work linking RDW to echocardiographic findings in PE has largely focused on isolated parameters such as TAPSE or PASP and has rarely incorporated modern measures of RV-PA coupling. Whether admission RDW reflects the integrated RV-PA interaction - and not merely contractility or pressure in isolation - has not been adequately addressed. Establishing this link would support RDW as a simple, universally available marker of RV vulnerability at first presentation, and would lay the groundwork for future prognostic and mechanistic studies.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Active hematologic malignancy or recent chemotherapy with myelosuppressive intent.

Red blood cell transfusion within the preceding 90 days.

Known hemoglobinopathy (e.g., sickle cell disease, thalassemia major).

Chronic dialysis or eGFR < 15 mL/min/1.73 m².

Trial population

Adults, hemodynamically stable with acute pulmonary embolism

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Echo-cardiography
Other intervention
All echocardiograms will follow a standardized acquisition protocol based on the American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations for RV assessment. Key elements: * Left lateral decubitus position when tolerated; semi-recumbent if dyspneic. * ECG-gated digital loops of at least three consecutive cardiac cycles for each view. * Mandatory views: parasternal long-axis and short-axis; apical four-chamber, RV-focused four-chamber, two-chamber, and three-chamber; subcostal four-chamber and IVC. * M-mode through the lateral tricuspid annulus for TAPSE. * Continuous-wave Doppler across the tricuspid valve for peak TR velocity (multiple windows attempted; agitated saline contrast may be used to improve TR signal at operator discretion). * Tissue Doppler at the lateral tricuspid annulus for S

Treatment groups

190 Participants

are divided into 1 treatment group

Group A: Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h1 intervention

Trial outcomes

Primary outcomes

assess the association between admission red cell distribution width (RDW) and right ventricular-pulmonary arterial coupling, measured by TAPSE/PASP ratio on transthoracic echocardiography performed within 24 hours of admission, in adults with acute PE

To assess the association between admission red cell distribution width (RDW) and right ventricular-pulmonary arterial coupling, measured by the TAPSE/PASP ratio on transthoracic echocardiography performed within 24 h of admission, in adults with acute pulmonary embolism

Time frame

24 hours

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

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