Hepatitis B virus (HBV) infection remains one of the most serious health problems worldwide. Patients with chronic HBV infection are at an increased risk for developing hepatic cirrhosis, hepatocellular carcinoma and even death. Although some predictive factors of the outcome of chronic HBV infection were identified, more precisely determine the factors which are associated with the outcome in non-selected patients with chronic HBV infection are still needed. The investigators purpose is to constitute a observational cohort of non-selected Chinese patients to create a database of epidemiological, clinical, biological, virological, immunologic and therapeutic parameters, in order to determine factors associated with the outcome of chronic HBV infection.
Patients with chronic HBV infection (defined as HBsAg positive for at least 6 months)
Co-infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV) and/or hepatitis D virus (HDV)
History of liver transplantation
History of hepatocellular carcinoma (HCC)
Patients chronically infected with hepatitis B virus
Cohort
Prospective
Not listed
Number of participants with antigen loss (HBeAg and HBsAg loss)
Cirrhosis
Hepatic decompensation
Development of hepatic decompensation will be defined by any of the following events: (1) Ascites or hepatic hydrothorax; (2)Variceal or portal hypertensive bleeding; (3)Hepatic encephalopathy
Hepatocellular carcinoma (HCC)
The diagnosis of HCC will be made using the American Association for the Study of Liver Disease criteria.
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