Real-time Opioid Study
ConditionSubstance Use Disorder (SUD)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorYale University
About this trial
This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is collecting first-in-human data in an OUD population. Investigators will assess tolerability of the intervention and collect preliminary data from 2-3 subjects monitoring changes in anhedonia, non-substance-related autobiographical memory recall, and meaning in life.
Eligibility criteria
Qualifiers
≥3 months of methadone treatment for OUD
Presence of anhedonia, as assessed via SHAPS
Baseline autobiographical memory deficit, as assessed via AMT
Disqualifiers
Failure to pass an MRI screening
Women who are pregnant
Psychosis, as assessed via Yale PRIME Early Psychosis Screening Test
Serious suicidal ideation
Trial design
Treatments tested in this trial
- real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback
Treatment groups
3 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov