The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD.
People who, at the time the letter is prepared or are identified by a clinician
Age ≥ 65 years
Stroke or TIA
Dementia
Text of brain scan report unreadable
Do not consent to take part in study procedures
Unable to consent
Unable to communicate by email, letter or telephone through language, speech disability or lack of address
People aged 65 years or older living in Scotland, UK
Cohort
Prospective
Functional and Cognitive scores
Other interventionWe will collect information about prior neurological symptoms, including prior symptoms suggestive of TIA or stroke, cognitive or motor symptoms, blood pressure and other known vascular risk factors, medicines, frailty, functional status, education, and employment status We will collect a baseline validated function and cognitive score, and take a sample of speech. Speech will be measured at assessment, in collaboration with the NeuroCARE Clinical and Digital Measures Module (22/SS/0010 IRAS No. 310885).
Functional scores
The investigators will measure day-to-day function with the Bristol Activities of Daily Living Scale, which is a 20-item assessment of daily living abilities for dementia. Each activity has 5 statement options (a - e) which refer to a different level of ability.
Cognitive scores
The investigators will measure concerns or anxiety about covert cerebrovascular disease using the Montreal Cognitive Assessment. It is a 10-minute test that assesses seven areas of cognition for a total possible score of 30 points. A score of 25 or less is indicative of cognitive impairment.
Speech samples
Speech will be measured at assessment, in collaboration with the NeuroCARE Clinical and Digital Measures Module (22/SS/0010 IRAS No. 310885).
Vascular events
At each assessment the investigators will ask about dementia, mild cognitive impairment and stroke symptoms.
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University of Edinburgh
Lead sponsor
NHS Lothian
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
