This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury. It aims to identify predictive EIT patterns related to extubation outcomes.
Age 18 or older
Hospitalized in intensive care for an acute brain injury.
Mechanical ventilation for more than 48 hours.
Ventilator withdrawal planned in the next few days
Pregnancy
Moribund patient / decision to stop treatment
Patient under state medical aid
Adult patients hospitalized in intensive care for an acute brain injury under invasive mechanical ventilation for more than 48 hours.
Cohort
Prospective
Internal Thoracic Impedance
Other interventionInternal Thoracic Impedance is a non-invasive an imaging technique which use low alternative current through electrodes placed on a belt positioned at the level of the patient's rib cage. Images are constructed according to conductivity measured.
Absolute ventral-to-dorsal ventilation difference
The Absolute V-D Difference will be calculated as the average of the ventilation in the ventral regions (ROI1 and ROI2) minus the average of the ventilation in the dorsal regions (ROI3 and ROI4) during mechanical ventilation weaning. This outcome will provide insights into regional pulmonary ventilation distribution and its correlation with extubation outcomes. This difference is calculated as follows: (ROI\_Value1 + ROI\_Value2)/2 - (ROI\_Value3 + ROI\_Value4)/2 expressed as a percentage.
Correlation between Absolute V-D Difference and Conventional Ventilatory Parameters
This outcome will evaluate how the Absolute V-D Difference correlates with other monitoring parameters, such as tidal volume, respiratory rate, SpO₂, and end-tidal CO₂ (EtCO₂), throughout the weaning process.
End-Expiratory Lung Impedance (ΔEELI)
The monitoring of ΔEELI will be continuous throughout the spontaneous breathing trial, which lasts 30 minutes. Monitoring will begin at a stable baseline 5 minutes prior to the start of the trial and will continue until 5 minutes after its completion. Three specific time points will be collected and analyzed: 1. EELI before the trial (baseline, 5 minutes prior), 2. EELI at the end of the trial (30 minutes), 3. EELI 5 minutes after resumption of mechanical ventilation
Correlation between ΔEELI and Extubation/Decannulation Failure
This secondary outcome assesses the relationship between changes in end-expiratory impedance (ΔEELI) and extubation or decannulation failure, defined as reintubation or need for reventilation within 7 days.
Pulmonary Compliance Variation during Ventilator Changes and Spontaneous Breathing Trials
This measure will track the changes in regional pulmonary compliance in response to adjustments in ventilator parameters (e.g., PEEP, tidal volume) and spontaneous breathing trials.
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
