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Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas

ConditionsOsteosarcomaBone TumorBone SarcomaHigh Grade SarcomaOsteoblastic OsteosarcomaChondroblastic OsteosarcomaFibroblastic OsteosarcomaConventional OsteosarcomaConventional Central Osteosarcoma of BoneLow Grade Central OsteosarcomaOsseous SarcomaOsseous TumorSmall Cell OsteosarcomaTelangiectatic OsteosarcomaUndifferentiated Pleomorphic SarcomaParosteal OsteosarcomaPeriosteal OsteosarcomaExtraskeletal OsteosarcomaRecurrent OsteosarcomaHigh Grade Surface OsteosarcomaOsseous AngiosarcomaOsseous FibrosarcomaOsseous LeiomyosarcomaOsseous Dedifferentiated ChondrosarcomaOsseous Mesenchymal ChondrosarcomaClear Cell Osteosarcoma
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorKlinikum Stuttgart

About this trial

The Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) is a non-interventional, multicentric, international, clinical and epidemiologic patient registry. The COSS-Registry collects key data on osteosarcomas or biologically related bone sarcomas. With that data collection we want to gain new scientific insights and results about this tumor disease, prognosis, surveillance and long-term effects.

Besides the data collection we would also like to foster the collection of biomaterial (tumor specimen and blood samples) for scientific research.

The stored material will be used to perform cell and molecular biological analyses to identify the causes of osteosarcoma, the prognosis and possible new treatment options.

As a starting point the donated biomaterial of registered patients will be analyzed firstly for the presence of a tumor predisposition by germline mutations.

In case of detected genetic variations that are related to the tumor disease and which may affect the patient's health and follow-up care (because of the potentially increased risk of developing other malignant tumors), affected patients will be informed and referred to genetic counseling.

Registry patients will be asked at the time of diagnosis if they wish to be informed about germline variants detected as part of the study procedures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

high-grade osteosarcoma (conventional and non-conventional)

parosteal, periosteal or extraosseous osteosarcoma

low grade central osteosarcoma

(osseous) Undifferentiated pleomorphic sarcoma (UPS)

Disqualifiers

no informed consent

Trial population

All patients irrespective of gender, age and tumour location

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Data Collection

Aims of the registry are the collection of clinical data to gain further insights about diagnosis, treatment, prognosis and risk factors of osteosarcoma and biologically related bone tumors.

Time frame
20 years (There will be continous subgroup analyses through study completion.)

Secondary outcomes

1

Reference Diagnostics

Aim of the registry is to give the frame for reference diagnostics.

Time frame
20 years (Recruitment period)
2

Collection of biologic samples.

Aim of the registry is the collection of biomaterial.

Time frame
20 years (Recruitment period)

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Klinikum Stuttgart

Lead sponsor

Klinikum Kassel GmbH (COSS-Biobank)

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: