Registry of Endovascular Treatment for Vertebrobasilar Dissecting Aneurysms in China

ConditionDissecting Aneurysm of Cerebral Artery

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-80

SponsorBeijing Tiantan Hospital

About this trial

The incidence of vertebrobasilar dissecting aneurysms (VBDAs) is about 1/100,000\~1.5/100,000, and it is one of the most important causes of stroke in young and middle-aged people. In recent years, with the development of medical imaging technology, the detection rate of this disease has been increasing year by year. The natural prognosis of VBDAs is complex and varied, with uncertainty: (1) it may have a benign course, and the imaging follow-up may show that the diseased vessels are repaired and improved or remain stable for a long period of time; (2) it may present with ischemic stroke caused by hemodynamic alteration or thromboembolism, which may result in severe neurological impairment; (3) it may occur as a result of rupture of aneurysms leading to subarachnoid hemorrhage, endangering the patient's life; (4) progressive enlargement of VBDAs causing occupying effects, which may be manifested as headache in mild cases, or hemiplegia of limbs and choking on drinking water in severe cases. Up to now, there is a lack of objective and uniform diagnostic and therapeutic guidelines for the natural regression of VBDAs and the benefits of surgery, and the treatment is mostly empirical, which makes it difficult to accurately determine the clinical prognosis of VBDAs and formulate appropriate treatment strategies.

Therefore, against the above background, we designed the present study. This study was a multicenter, prospective, registry study. We enrolled patients with unruptured VBDAs who met the inclusion and exclusion criteria, and a multi-disciplinary team formulated the treatment modalities for the patients, which were categorized into the conservative observation group, the stent-assisted coiling group, and the flow diverter group. The aim of our study was to investigate the effects of different treatment modalities on the prognosis of patients with VBDAs, as well as to stratify the risk factors of the patients, to explore the individualized treatment modalities of the patients, and to improve the diagnosis and treatment of this clinically refractory cerebrovascular disease.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-80 years old;

Patients diagnosis of "unruptured vertebrobasilar dissecting aneurysm".

Disqualifiers

Patients did not undergo a cranial MRI;

Missing critical clinical baseline;

Missing pre-treatment imaging;

Receiving microsurgery;

Trial population

Patients diagnosis of "unruptured vertebrobasilar dissecting aneurysm".

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Multi-disciplinary assessment
Other intervention
1. Comprehensive evaluation was performed by multi-disciplinary experts to assess the prognosis of unruptured VBDAs and develop appropriate treatment strategies. 2. Preoperative cranial MRI, CTA, DSA and other imaging tests were used to determine the aneurysm site, morphology, size, presence of compression symptoms, and whether it was accompanied by an intramural hematoma.

Treatment groups

2,000 Participants

are divided into 3 treatment groups

Group A: Conservative management group1 intervention

Group B: Stent-assisted coiling group0 interventions

Group C: Flow diverter group0 interventions

Trial outcomes