Registry of Patients With Takotsubo Syndrome

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-110
SponsorNYU Langone Health

About this trial

Takotsubo syndrome is a condition which mimics acute myocardial infarction, and is diagnosed in 1.5% to 2.2% of patients referred to hospital with suspected acute coronary syndrome. It is also known as broken heart syndrome, takotsubo cardiomyopathy, stress cardiomyopathy and apical ballooning cardiomyopathy, among other names. The pathogenesis of this disorder is not well understood. Possible mechanisms include catecholamine excess, coronary artery spasm, microvascular dysfunction, among others. This is a multicenter, nation-wide, observational study of patients who were previously diagnosed with takotsubo syndrome. The investigators aim to use this registry to help plan and carry out further studies and to improve understanding of the pathophysiologic mechanisms of this syndrome. In addition participants will be followed for events, and to monitor quality of life and stress.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Physician diagnosis of takotsubo syndrome

Age>18 years

Disqualifiers

None

Trial population

Patients with history of takotsubo syndrome

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Major Adverse Cardiac Events

Medical record review and patient report of repeat takotsubo event, MI, heart failure, unstable angina, chest pain ER visit, cardiovascular death, stroke

Time frame
up to 10 years

Secondary outcomes

1

Quality of life assessed using the Patient Reported Outcome Measurement Information System (PROMIS-10) questionnaire

Measure of quality of life

Time frame
every four months up to 10 years
2

Anxiety is assessed using the Hospital Anxiety and Depression Scale (HADS-A)

Measure of anxiety

Time frame
every four months up to 10 years
3

Depression assessed using the Patient Health Questionnaire (PHQ-9)

Measure of depression

Time frame
every four months up to 10 years
4

Perceived stress is measured using the Perceived Stress Scale (PSS-10)

Measure of perceived stress

Time frame
every four months up to 10 years

Other outcomes

Sponsors and contacts

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