Relationships Between Muscle Activity, Soft Tissue Changes, and Movement Strategies in Individuals With Chronic Low Back Pain

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Rennes 2

About this trial

This study aims to explore, in patients with chronic non-specific low back pain (cnsLBP), the relationships between lumbar muscle activity, structural and morphological characteristics of the paraspinal muscles, and movement strategies, during a functional, ecological task: walking. To do this, we will compare a group of cnsLBP patients with a group of asymptomatic subjects, combining several types of measurements taken at different walking intensities: spinal kinematics (movement strategies), electromyographic activity of the lumbar muscles, and structural parameters of the paraspinal muscles (stiffness and thickness). The objective is twofold: first, to identify any significant differences between cnsLBP patients and healthy subjects on these combined parameters; second, to explore the interactions between these three dimensions (muscle activity, muscle structure, movement strategy) in order to better understand their relationships with pain and with how CNSLBP functions during physical activity. This multidimensional, ecological approach could also help identify subgroups within the cnsLBP population, reflecting the clinical heterogeneity already documented in the literature. Ultimately, the expected results will contribute to a better understanding of the biomechanical and neuromuscular mechanisms involved during physical activity in these patients, and will provide objective elements to help individualize physical activity recommendations according to each patient's profile.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult aged 18 to 65 years (inclusive)

Have freely given written informed consent

Present with pain located between the thoracolumbar junction and the inferior gluteal fold, with or without pain in one or both legs

This pain must have been present for more than 12 weeks, on a daily or near-daily basis (at least 4 days out of 7)

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Supervised Progressive Walking Test

    Other intervention

    After a warm-up period on the treadmill, the test involves walking, starting at a speed of 3 km/h and increasing the speed by 0.5 km/h every 2 minutes, up to a maximum of 7 km/h. The speed of 7 km/h is a target speed and is not mandatory.

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Non-specific Chronic Low Back Pain participantsExperimental treatment 1 intervention
Group B: Asymptomatic participantsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in muscle stiffness of the erector spinae and multifidus muscles between rest and after physical activity

Change in muscle stiffness, measured by shear modulus using shear-wave elastography, of the erector spinae and multifidus muscles, between rest and after physical activity.

Time frame
As the study consists of a single session, the time frame is between the pre-walking-test and post-walking-test assessments.

Secondary outcomes

1

Ultrasound morphological measurements

Measurement of the cross-sectional area and thickness-as determined by ultrasound-of the erector spinae and multifidus muscles at rest.

Time frame
Data were collected during the experimental session.
2

Electromyographic activity

Lumbar muscle activations during three-dimensional lumbar movements and while walking

Time frame
Data were collected during the experimental session.
3

Kinematics

The kinematics of the lumbopelvic-femoral complex (segmental velocity and acceleration, joint angles) during three-dimensional movements and while walking.

Time frame
Data were collected during the experimental session.
4

General data

Age, sex, height, weight, body mass index, and socioeconomic status are recorded.

Time frame
Data were collected during the experimental session

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: