Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorFatih Sultan Mehmet Training and Research Hospital
About this trial
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.
This randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter/eyeball transverse diameter ratio (ONSD/ETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.
The findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥18 years
American Society of Anesthesiologists (ASA) physical status I-III
Scheduled for elective cerebral aneurysm coil embolization under general anesthesia
Planned endotracheal intubation
Disqualifiers
Emergency procedures
Hemodynamic instability before induction of anesthesia
Severe cardiac conduction abnormalities or clinically significant arrhythmias
Contraindication or allergy to remifentanil or esmolol
Trial design
Design model
Parallel
Treatments tested in this trial
Remifentanil
DrugRemifentanil 0.5-1 µg/kg IV administered over 90 seconds before endotracheal intubation.
Esmolol
DrugEsmolol 0.5-1 mg/kg IV administered over 90 seconds before endotracheal intubation.
Treatment groups
84 Participants
are divided into 2 treatment groupsGroup A: remifentanil groupExperimental treatment 1 intervention
Group B: Esmolol GroupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in ONSD/ETD Ratio at 5 Minutes After Endotracheal Intubation
Difference between baseline (pre-intubation) and 5-minute post-intubation optic nerve sheath diameter-to-eyeball transverse diameter ratio (ONSD/ETD).
Time frame
5 minutes after endotracheal intubationSecondary outcomes
1
Change in ONSD/ETD Ratio at 10 Minutes After Endotracheal Intubation
Difference between baseline (pre-intubation) and 10-minute post-intubation optic nerve sheath diameter-to-eyeball transverse diameter ratio (ONSD/ETD).
Time frame
10 minutes after endotracheal intubation2
Change in Mean Arterial Pressure
Changes in mean arterial pressure measured before intubation, 5 minutes after intubation, and 10 minutes after intubation.
Time frame
Baseline, 5 minutes, and 10 minutes after intubation3
Change in Heart Rate
Changes in heart rate measured before intubation, 5 minutes after intubation, and 10 minutes after intubation.
Time frame
Baseline, 5 minutes, and 10 minutes after intubation4
Vasopressor Requirement
Requirement for vasopressor administration during the study period following endotracheal intubation.
Time frame
From intubation until 10 minutes after intubationSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: