This study aims to evaluate the sedative efficacy and safety of remimazolam combined with oliceridine in elderly patients undergoing painless gastrointestinal endoscopy. Elderly patients often face higher risks of respiratory and hemodynamic depression during clinical sedation. This trial will investigate whether the combination of remimazolam and oliceridine can provide stable sedation, maintain stable vital signs, and reduce the incidence of adverse events such as hypoxemia and postoperative cognitive fluctuation in this vulnerable population.
Elderly individuals scheduled to undergo painless gastrointestinal endoscopy.
Age between 65 and 80 years.
Body mass index (BMI) between 18 and 30 kg/m².
American Society of Anesthesiologists (ASA) physical status I-III (ASA III patients eligible only with mild-to-moderate dysfunction of a single organ system, without severe organ failure, and considered able to tolerate the procedure).
Allergy or contraindication to remimazolam, oliceridine, or sufentanil.
Liver or renal failure (Child-Pugh class C or eGFR < 30 mL/min).
Systemic infection, immunosuppression, coagulation disorder, upper gastrointestinal bleeding, or intestinal obstruction.
History of opioid dependence or long-term use of psychotropic drugs.