Remimazolam for Postoperative Sleep in Elderly Patients

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-80
SponsorGeneral Hospital of Ningxia Medical University

About this trial

Postoperative sleep disturbance (PSD) is highly prevalent in elderly patients undergoing laparoscopic radical resection of colorectal cancer. Although remimazolam has shown favorable sedative properties and may alleviate perioperative stress, its effects on postoperative sleep architecture remain poorly understood. Polysomnography (PSG), the gold standard for objective sleep assessment, has not been widely used to evaluate these effects in this population. Therefore, this study employs a randomized controlled trial design to verify whether remimazolam is superior to propofol in preserving postoperative sleep quality, thereby offering more evidence-based options for anesthetic management in elderly patients undergoing laparoscopic colorectal cancer surgery.

Eligibility criteria

Qualifiers

Aged between 65 and 80 years.

Scheduled for elective laparoscopic radical resection of colorectal cancer.

American Society of Anesthesiologists (ASA) physical status class II-III.

Able to understand the study protocol and provide written informed consent.

Disqualifiers

Known allergy to any study medications.

Preoperative sleep disorder (Pittsburgh Sleep Quality Index [PSQI] score > 10).

Regular use of sedatives, antipsychotics or hormonal drugs within the past month.

Preoperative cognitive impairment, screened using the education-adjusted Mini-Mental State Examination (MMSE).

Trial design

Treatments tested in this trial

  • Remimazolam
  • propofol

Treatment groups

84 Participants
are divided into 2 treatment groups

Locations

This trial has no locations