The goal of this clinical trial is to learn how a remotely monitored high-intensity interval training (REMM-HIIT) affects the cardiorespiratory fitness and physical function for patients planning to undergo stem cell transplantation. The main questions it aims to answer are:
Is there a change in the participant's cardiorespiratory fitness level? Is there a change in the participant's physical function?
Researchers will compare the REMM-HIIT program to a control group of participants who do not take part in the training program to see if REMM-HIIT helps improve stem cell transplantation outcomes.
Participants will:
* Complete cardiopulmonary exercise testing (CPET) 4 times during the study * Do basic tests to measure physical function 6 times during the study * Answer questions about their life and how they are feeling 6 times during the study * Wear a device to keep track of step counts and heart rate daily * Keep a log of every time they exercise throughout the study * Optionally, provide blood and stool samples 6 times during the study
Plan to undergo allogeneic hematopoietic stem cell transplant in 4-12 weeks after enrollment on this study.
Age 18-80 years
Able to read/write English (as many participant-reported outcome measures lack validated translations in other languages)
Unable or unwilling to follow coaching
Functional impairment resulting in inability to exercise
recent (<6 months) acute cardiac event;
unstable angina;
Parallel
High Intensity Interval Training
BehavioralThe intervention will consist of three 30-minute training sessions/week, each starting with a five-minute warm-up, followed by 20 minutes of interval training, and ending with a five-minute cool-down. The interval training will consist of 10 alternating high- and low-intensity intervals, with a 1:1 work-to-rest ratio (one minute of high intensity followed by one minute of low-moderate intensity). As participants' fitness improves, the interval intensity will increase accordingly.
Change in Cardiorespiratory Fitness
Change in cardiorespiratory fitness as measured by the difference in peak rate of oxygen consumption (VO2peak) in mL/(kg\*min) from baseline to the pre-hematopoietic stem cell transplant (HCT) timepoint; a higher number for VO2 peak indicates greater cardiorespiratory fitness.
Change in Physical Function (Six Minute Walk Test Distance)
The change in physical function as measured by the difference in six minute walk test distance in meters from baseline to the pre-hematopoietic stem cell transplantation (HCT) timepoint; a greater number of meters walked indicates a higher level of physical function.
Effect on Health-related Quality of Life (Physical Activity/Short Physical Performance Battery)
Effect on health-related quality of life (physical activity) as measured by performance on the Short Physical Performance Battery, which results in a score from 0 to 12 points, with a higher number indicating better physical performance.
Effect on Health-related Quality of Life (Physical Activity/30-Second Sit-to-Stand Test)
Effect on health-related qulaity of life (physical activity) as measured by the 30-second sit-to-stand test, which measures the number of times an individual can stand up from a chair and sit back down within 30 seconds, with a higher number indicating greater fitness.
Effect on Health-related Quality of Life (Physical Activity/Fried Frailty)
Effect on health-related quality of life (physical activity) as measured by the Fried Frailty assessment, which results in a score from 0 to 5, with a higher number indicating greater frailty.
Effect on Health-related Quality of Life (Physical Activity/Fall Question)
Effect on health-related quality of life (physical activity) as measured by the Fall Question, a structured questionnaire asking about any history of falls, with a higher number of falls indicating greater fall risk and physical vulnerability.
Effect on Muscle Health (Resting Energy Expenditure)
The effect on muscle health as measured by resting energy expenditure.
Effect on Muscle Health (Intramuscular Adipose Tissue)
The effect on muscle health as measured by amount of intramuscular adipose tissue assessed using biopsied muscle tissue.
Effect on Muscle Health (Glycogen Stores)
The effect on muscle health as measured by amount of glycogen stores in muscle assessed using biopsied muscle tissue.
Effect on Muscle Health (Muscle Mitochondrial Metabolism)
The effect on muscle health as measured by muscle mitochondrial metabolism assessed in biopsied muscle tissue.
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