Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
ConditionMajor Depressive Disorder (MDD)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Oxford
About this trial
Previous work demonstrated that individuals are able to self-regulate their ventral tegmental area (VTA) activity using real-time biofeedback. The current study expands this approach to a larger sample with repeated training sessions to more robustly characterize the effects of VTA modulation. The study will assess change in mood and motivation-related measures, as well as neural activity and connectivity changes.
Eligibility criteria
Qualifiers
Male or female aged 18-65 years;
Meets DSM-5 criteria for major depressive disorder (MDD) as determined by the Structured Clinical Interview for DSM-5 Axis Disorders (SCID) or the Mini International Neuropsychiatric Interview (MINI); with a current major depressive episode.
Participants must have a level of understanding of the English language sufficient to agree to all tests and examinations required by the study and must be able to participate fully in the informed consent process.
Disqualifiers
Current or history of schizophrenia or other psychotic disorder, neurodevelopmental disorder, neurocognitive disorder or cognitive impairment
Active substance use disorder within the past 1 year;
Any unstable medical illnesses;
Women who are pregnant;
Trial design
Treatments tested in this trial
- Active Biofeedback
- Sham Biofeedback
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Oxford
Lead sponsor
Wellcome Trust
Collaborator
Source ClinicalTrials.gov