The purpose of this study is to evaluate the efficacy and electrophysiology of repetitive transcranial magnetic stimulation in the treatment of essential tremor.
Diagnosed as essential tremor conforming to the diagnostic criteria for essential tremor in the tremor group of the International Parkinson's and Movement Disorders Society (IPMDS).
Signed informed consent form.
Complicated with brain organic diseases, epilepsy, other mental diseases, family history of dementia, metal devices implanted in the body and any contraindications to TMS;
History of craniocerebral surgery;
TMS cannot cooperate;
TMS-EEG examination artifacts are obvious, or cannot be analyzed due to other technical reasons.
Parallel
real rTMS
Devicetreated with 1HZ rTMS 1800 pulses / day,for 10 days
sham rTMS
Devicetreated with sham rTMS 1800 pulses / day,for 10 days
The efficacy of the treatment on the essential tremor evaluated by Essential Tremor Rating Assessment Scale (TETRAS) score
The TETRAS is widely used tremor evaluation scale.TETRAS has been used for evaluation tremor in patients with essential tremor focuses primarily on the assessment of activities of daily living and tremor.The TETRAS score ranges from 0 to 112. The higher the TETRAS score, the more severe the symptoms.
Changes from baseline in tremor analysis
This outcome reflects quantitative changes in the patient's tremor.
Changes from baseline in TMS-EEG
Amplitudes of various frequency bands in each cortical region of TMS-EEG reflects change in the patient's brain network.
Change in Non-Motor Symptoms Rating Scale (NMSS) score from baseline
This outcome reflects the efficacy of non-motor symptoms. NMSS is a widely used non-motor symptom rating scale that includes 9 domains, The NMSS score ranges from 0 to 360，with higher scores associated with more severe symptoms.
Change in Mini-Mental State Examination (MMSE) score from baseline
The MMSE is widely used to assess cognition. The MMSE score ranges from 0 to 30. The higher the MMSE score is, the better the cognitive function is.
Change in Montreal Cognitive Assessment (MOCA) score from baseline
MoCA is widely used to assess cognitive abilities. MOCA scores range from 0 to 30. The higher the MOCA score, the better the cognitive function.
Click on the lead sponsor to view all of their trials.
