Cross-sectional observational study to improve MRI data acquisition techniques by optimising MRI sequences for multiple organs and assessing the repeatability and reproducibility of multiparametric MRI, in healthy volunteers.
Adults aged 18 years and older
Participant is willing and able to give informed consent for participation in the study
The participant has a level of English proficiency that allows them to communicate well with the investigator and could comply with study requirements.
The participant is willing and able to undergo MRI scan.
Any contraindication to magnetic resonance imaging (incl. pregnancy, nonremovable electronic implants including cochlear implants, infusion pumps, and pacemakers, shrapnel injury, severe claustrophobia, allergic reaction to contrast agents)
Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study
The participant may be excluded where body habitus is likely to make MRI or echocardiography/ultrasound uncomfortable or unlikely to yield analysable images, and BMI more than 40-45
Study participants will be adult volunteers aged 18 and over, without a contraindication to magnetic resonance imaging.
Other
Cross-sectional
Not listed
Development of MRI sequences
Development of sequences which will be used to collect good quality data on multiple organs across different MRI scanners and to ensure that desirable images are obtained within reasonable amount of time.
Sequence and parameter validation
Validation of a list of sequences and parameter details
Assessment of MRI metric repeatability
Assessment of repeatability of the MRI metrics across 2 separate MRI acquisitions on the same scanner using statistical methods
Assessment of MRI metric reproducibility
Assessment of reproducibility of the MRI metrics in the same participants scanned on separate MRI scanners
Assessment of participant comfort during scan
Assessment of participant comfort during different MRI protocols with participant questionnaires.
