Mining AIS biomarkers, elucidating the new mechanism of AIS pathogenicity, constructing risk prediction models, optimizing AIS precise diagnosis and treatment techniques, formulating precise diagnosis and treatment protocols and technical specifications for AIS combined with Chinese and Western medicine with independent intellectual property rights, and realizing the full coverage of Zhejiang Province by the end of 2026, so as to form the "Zhejiang experience" of AIS diagnosis and treatment.
Patients diagnosed with AIS;② Sex is not limited, age 10-18 years old; ③ Those who sign the informed consent and can cooperate with follow-up visits; ④ Those who can cooperate with X-ray, chemical test, genetic test and other examination and evaluation for the measurement of relevant indexes.
Subjects with spine-related diseases such as Marfan's syndrome;
Subjects with previous ankylosing spondylitis, spinal neurofibroma, spinal tuberculosis, spinal trauma and other spine-related diseases;
Subjects with combined serious medical diseases and psychiatric patients;
Those with ECOG score > 2, which may have an impact on the study results;
Parallel
Low risk experimental group
BehavioralGuiding + Manipulation + Traditional Chinese Medicine
Medium risk experimental group
BehavioralGuiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces
High risk experimental group
GeneticGuiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces + Specialized Inpatient Rehabilitation
Control group COBB 10-20°
BehavioralSpecific Exercise Therapy
Control group COBB 20-45°
BehavioralOrthopedic Braces + Specific Exercise Therapy
Control group COBB >45°
BehavioralOrthopedic Braces + Specific Exercise Therapy + Recommended Surgery
Experimental group (AIS group)
Other interventionMolecular marker exploration and validation
Control group (healthy control)
Other interventionMolecular marker exploration and validation
Controlled follow-up before and after AIS
Other interventionConstruction and validation of AIS risk prediction model completed
Cobb Angle
Cobb's angle is an angle used to measure the severity of scoliosis by measuring the angle of lateral curvature to assess the degree of scoliosis.
Trunk Rotation Degree -Angle of Trunk Rotation
The patient stood with feet shoulder-width apart and bent forward with hands to palms, and the maximum degree of spinal razorback was measured with the Scoliometer Scoliosis Screening Scale.
Coronal Balance
A plumb line is usually used to determine coronal plane balance. In the coronal plane of a normal spine, a plumb line leading from the center of the C7 vertebra will pass through the center of the sacrum or within 1 cm to the left and right of the S1 spinous process.
Sagittal Balance
Sagittal Balanced descriptions in the sagittal plane are an important way to assess scoliosis and its impact on body structure and function.
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