Research on the Characteristics of Chronic Airway Diseases (asthma, COPD)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-80
SponsorHenan University of Traditional Chinese Medicine
About this trial
This study will to investigate the correlation between the characteristics of the population with chronic airway diseases (asthma, chronic obstructive pulmonary disease) and syndromes, in order to reveal the disease and syndrome features of the population; Secondly, screening and identifying biomarkers for asthma and chronic obstructive pulmonary disease to provide a basis for precise prevention and treatment of the disease.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Meets the diagnostic criteria for asthma or COPD.
Age of athma range from 12 years to 80 years.Age of COPD range from 18 years to 80 years.
The investigators agreed to participate in this clinical study by voluntarily signing an informed consent form.
Disqualifiers
Patients with respiratory diseases such as interstitial lung disease, lung malignant tumor, lung infectious diseases, pneumothorax, pleural effusion, etc., which affect the syndrome differentiation.
Patients with combining severe cardiovascular and cerebrovascular diseases, severe liver and kidney diseases, severe hematological malignancies, etc., affecting syndrome differentiation.
Patients with delirium, dementia, various mental illnesses.
Trial population
Chronic airway disease is a group of non-specific chronic airway inflammatory diseases, among which bronchial asthma and chronic obstructive pulmonary disease are the most common and representative. There are approximately 45.7 million asthma patients aged 20 and above in China; Nearly 100 million patients with chronic obstructive pulmonary disease are over 40 years old. Traditional Chinese and Western medicine have certain advantages in preventing and treating chronic airway diseases, but there are still key issues that restrict the improvement of therapeutic effects: the complex characteristics of chronic airway diseases, unclear disease syndrome relationships, and clear disease syndrome characteristics provide a basis for precise prevention and treatment of diseases
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Participants fill out the questionnaire
Other interventionParticipants fill out the questionnaire
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Inflammatory Phenotype of Chronic Airway Diseases
The inflammation phenotype will be determined by measuring the different proportions of eosinophils, neutrophils and mast cells in induced sputum and peripheral blood.The inflammatory phenotypes of asthma can be divided into eosinophil asthma(eosinophil \> 1.01%) ， neutrophil asthma(neutrophil \> 61%)， Oligocellular asthma (eosinophil \> 61%)and mixed cell asthma(eosinophil \> 1.01%, neutrophil \> 61%).
Time frame
Each registered patient is measured only once at the time of registration.2
The Traditional Chinese Medicine Syndromes of Athma
Using the "Diagnostic Criteria for Traditional Chinese Medicine Syndromes of Bronchial Asthma (2016 Edition)" to assess the TCM syndromes of asthma.
Time frame
Each registered patient is measured only once at the time of registration.3
The Traditional Chinese Medicine Syndromes of COPD
Using the "Diagnostic Criteria for Traditional Chinese Medicine Syndromes of Chronic Obstructive Pulmonary Disease (2011 Edition)" to assess the TCM syndromes of COPD.
Time frame
Each registered patient is measured only once at the time of registration.4
General Demographic Data
General demographic data, including name, age（years）, sex(male / female), BMI(kg/m2), occupation, smoking history (years)and drinking history(years), will be recorded.
Time frame
Each registered patient is measured only once at the time of registration.Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Henan University of Traditional Chinese Medicine
Lead sponsor
West China Hospital
Collaborator
Beijing Yikang Medical Technology Co., Ltd
Collaborator
Tongji Hospital
Collaborator
Source ClinicalTrials.gov
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