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Resistance Training-induced Adaptations in Children

ConditionHealthy Participants
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-12
SponsorBrock University

About this trial

Resistance exercise training (RET) in children and adolescents has become a popular activity, with a growing body of evidence supporting its use. Numerous studies indicate that it is safe and effective at increasing muscular strength, improving sport performance, and mitigating injury risk. Despite this evidence, there are still many unknowns with RET in children, including its mechanisms of action in enhancing muscle strength.

Neural and muscular mechanisms can improve muscle strength following RET. Neural factors include improved recruitment and firing of an individual's muscle cells, and muscular factors primarily include an increase in the size of the muscle (hypertrophy). In children, little is known about how these mechanisms relate to muscle strength.

Therefore, the purpose of this study is to non-invasively assess the mechanisms of RET-induced strength increases in children performing 12 weeks of RET, compared with a non-training control group. Broadly, muscular adaptations will be assessed using ultrasound measures, while neural mechanisms will be assessed using surface electromyography decomposition.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

healthy

able to exercise

Disqualifiers

have consumed any medications in the past year which may affect muscle function,

have any prior injuries or medical diagnoses associated with altered muscular function,

have had an injury in the past 6 months that would limit the movements required for the training and assessment protocols,

have performed resistance training in the past 6 months or currently participate in competitive sports (i.e., outside of school) more than 2x/week.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Resistance training

    Other intervention

    progressive resistance training, 12 weeks, 2 times per week

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: TrainingActive comparator 1 intervention
Group B: ControlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

muscle strength

1 repetition maximal - knee extension

Time frame
From enrollment to the end of training at 12 weeks
2

Peak torque

Peaktorque will be measured during isokinetic and isometric maximal contractions of the knee extensors

Time frame
From enrollment to end of training at 12 weeks

Secondary outcomes

1

Motor unit activation

Surface electromyography signal during a ramped contraction will be used to assess changes in motor unit firing rates

Time frame
from enrollment to end of training at 12 weeks
2

muscle cross sectional area

B-mode ultrasound will be used to capture panoramic images of multiple muscles of the thigh. These images will be used to assess changes in muscle cross sectional area.

Time frame
from enrollment to end of training at 12 weeks
3

Blood pressure regulation

Blood pressure will be assessed before and after maximal voluntary apnea, as well as before and after isometric handgrip exercise.

Time frame
from enrollment to end of training at 12 weeks

Other outcomes

Locations

1

Map coordinates are unavailable for these locations. Locations are shown below instead.

Brock UniversityRecruitingL2S3A1, Saint Catharines, OntarioCanadaCanada

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Brock University

Lead sponsor

Source ClinicalTrials.gov
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