Resistance Training to Individuals for Cognitive Impairment With Dementia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50+
SponsorUniversity of Beira Interior
About this trial
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. First the investigators will analyze the effects of a single resistance training session (acute effects) with one and three sets on hemodynamic and physical performance in individuals with mild cognitive impairment. After, the investigators will analyze the effects of an 8-week resistance training program with one or three sets on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. The investigators hypothesize that a single resistance training session of one or three sets will increase the acute hemodynamic and physical performance stress in individuals with mild cognitive impairment, although with a higher magnitude in the session with three sets. Furthermore, we hypothesize that eight weeks of resistance training with one or three sets will induce similar improvements in cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Clinical diagnosis of mild cognitive impairment
SPPB score ≥ 3 points
Willingness to participate in the interventions and collaborate with the research team
Must be able to provide informed consent (oral or written)
Disqualifiers
Severe dementia
Severe comorbidity that negatively influences participation in the intervention
Color blindness
Fractures in the last three months
Trial design
Design model
Factorial
Treatments tested in this trial
One Resistance Training Set (Single Session)
Other interventionThe participants will perform a resistance training session with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions at 55% 1RM in the chest press, iv) 1 set of 10 repetitions in the sit-to-stand exercise, v) 1 set of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Three Resistance Training Sets (Single Session)
Other interventionThe participants will perform a resistance training session with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions at 55% 1RM in the chest press, iv) 3 sets of 10 repetitions in the sit-to-stand exercise, v) 3 sets of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
One Resistance Training Set (8 Weeks)
Other interventionThe participants will perform eight weeks of resistance training with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions between 40-60% 1RM in the chest press, iv) 1 set of 6-12 repetitions in the sit-to-stand exercise, v) 1 set of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Three Resistance Training Sets (8 Weeks)
Other interventionThe participants will perform eight weeks of resistance training with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions between 40-60% 1RM in the chest press, iv) 3 sets of 6-12 repetitions in the sit-to-stand exercise, v) 3 sets of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Control (8 Weeks)
Other interventionThe participants in the control group will maintain their regular daily activities without performing any form of physical exercise.
Treatment groups
80 Participants
are divided into 5 treatment groupsGroup A: One Resistance Training Set (Single Session)Experimental treatment 1 intervention
Group B: Three Resistance Training Sets (Single Session)Experimental treatment 1 intervention
Group C: One Resistance Training Set (8 Weeks)Experimental treatment 1 intervention
Group D: Three Resistance Training Sets (8 Weeks)Experimental treatment 1 intervention
Group E: Control (8 Weeks)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Systolic blood pressure (SBP)
In the cross-over study (acute effects), the SBP will be assessed through a blood pressure device.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessions2
Handgrip strength (HGS)
In the cross-over study (acute effects), the HGS will be assessed through an analogic dynamometer.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessions3
Dementia Rating Scale-2 (DRS-2)
In the eight-week study, the DRS-2 questionnaire will be applied to analyze the overall level of cognitive function through five subscales: attention, initiation/perseveration, construction, conceptualization, and memory.
Time frame
Change from baseline to week 84
Brain-Derived Neurotrophic Factor (BDNF)
In the eight-week study, the BDNF protein levels will be analyzed through specific blood testing kits.
Time frame
Change from baseline to week 8Secondary outcomes
1
Diastolic blood pressure (DBP)
In the cross-over study (acute effects), the DBP will be assessed through a blood pressure device.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessions2
Heart rate (HR)
In the cross-over study (acute effects), the HR will be assessed through a blood pressure device.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessions3
Tympanic temperature (TT)
In the cross-over study (acute effects), the TT will be assessed through a tympanic thermometer.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessions4
Five-repetition sit-to-stand (5STS)
In the cross-over study (acute effects), the 5STS time will be recorded through a chronometer.
Time frame
Change from baseline to 0 minutes and 72 hours after the sessionsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Beira Interior
Lead sponsor
Research Center in Sports Sciences, Health Sciences and Human Development
Collaborator
Source ClinicalTrials.gov