Respiratory Admittance by Oscillometry in Children
ConditionAsthma (Diagnosis)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age5-16
SponsorCentral Hospital, Nancy, France
About this trial
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during bronchoconstriction induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance during an ECT.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged 5 to 16 years
Children addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026
Children with interpretable and reproducible oscillometric measurements
Children with interpretable and reproducible spirometric measurements
Disqualifiers
Children who performed only spirometric measurements
Children who performed only oscillometric measurements
Children whose oscillometric and spirometric measurements are non-interpretable
Children whose oscillometric and spirometric measurements are non-reproducible
Trial population
Data of children aged 5 to 16 years addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026 to the Pediatric Function Testing Department who have oscillometric and spirometric interpretable and reproducible measurements
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
144 Participants
are grouped into 2 trial groupsGroup A: Children with positive response to exercise challenge test
Group B: Children with NEGATIVEresponse to exercise challenge test
Trial outcomes
Primary outcomes
1
Diagnostic performance of Ars
Area under the ROC curves (AUC) for response to exercise challenge of Ars (computed from oscillometric parameters) compared with AUC of respiratory resistance to identify children with a positive challenge test and children with a negative challenge test
Time frame
Through study completion, an average of 1 monthSecondary outcomes
1
Sensitivity of Ars
Sensitivity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the sensitivity of respiratory resistance to identify children with a positive challenge test
Time frame
Through study completion, an average of 1 month2
Specificity of Ars
Specificity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the specificity of respiratory resistance to identify children with a positive challenge test
Time frame
Through study completion, an average of 1 monthLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: