The purpose of this study is to define the standard use of TCM treatment regimen as the TCM cohort group and the non-TCM cohort group of those who use conventional Western medicine treatment without the standard TCM treatment regimen through a multi-center, large-sample prospective cohort study design. To evaluate the clinical efficacy and safety of TCM treatment regimens in the treatment of bronchial asthma, and to provide high-quality evidence for the promotion and application of TCM syndrome differentiation treatment in bronchial asthma.
Patients who meet the diagnosis of bronchial asthma;
Age 18~80 years old;
Have not participated in other clinical studies within 1 month before enrollment;
Voluntarily participate in the study and sign the informed consent form.
Patients with respiratory failure and mechanical ventilation during acute asthma exacerbation;
Delirium, impaired consciousness, dementia, and various mental illnesses;
Patients with other lung diseases such as COPD, lung abscess, cystic fibrosis, bronchiectasis, etc., and severe liver and kidney diseases;
Patients with neuromuscular diseases that affect respiratory motor function and are unable to complete the six-minute walk test;
Patients who are eligible for a diagnosis of bronchial asthma disease
Cohort
Prospective
Not listed
Asthma control rate
According to the composite indicators such as symptoms, medication and pulmonary function test results, the clinical control level of asthma was divided into complete control, partial control and uncontrolled, and the asthma control rate of patients was evaluated according to the clinical control level of asthma.
Number of exacerbations
The number of acute attacks is mainly recorded
Asthma exacerbation severity
Worsening lung function during asthma attacks is characterized by decreased expiratory flow, and the severity of the exacerbation can be graded by the patient's symptoms, lung function, and arterial blood gas analysis.According to the frequency of daytime and nighttime asthma attacks and pulmonary function test results, the patients were divided into 4 grades, namely: 1 intermittent attack; 2 mild persistent; 3 moderate persistent and 4 severe persistent.The severity of the asthma attack was assessed using a rating scale.
Change in severity of chronic persistent disease
Although the patient does not have an acute attack of asthma, there are still symptoms such as wheezing, cough, chest tightness and other symptoms with different frequency and degrees for a long time, which may be accompanied by decreased pulmonary ventilation function. The severity of chronic persistent asthma can be classified into four levels: intermittent, mildly persistent, moderately persistent, and severely persistent, according to the frequency of daytime and nighttime asthma symptoms and the results of pulmonary function tests.The severity of the asthma attack was assessed using a rating scale.
The dose used by glucocorticoids
Corticosteroids are the drug of choice for long-term asthma treatment. The vast majority of patients with chronic persistent asthma are well controlled by inhaling low-dose corticosteroids (equivalent to 400 micrograms of budesonide per day).
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Henan University of Traditional Chinese Medicine
Lead sponsor
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Collaborator
Tianjin University of Traditional Chinese Medicine
Collaborator
Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
Collaborator
Hebei Provincial Hospital of Traditional Chinese Medicine
Collaborator
Peking University People's Hospital
Collaborator
The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
Collaborator
The First Affiliated Hospital of Zhengzhou University
Collaborator
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Collaborator
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Collaborator
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