Health TrialsbyHealthPanel

Resting State Changes Following Theta Burst Stimulation

ConditionBrain Connectivity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorNicholas Balderston, PhD

About this trial

Transcranial magnetic stimulation (TMS) is increasingly being applied to effectively treat mental illness, however efforts to quantify the effects of TMS on the network architecture of the brain have largely been limited in scope and tied to specific neurologic and psychiatric disorders. The objective of the current work is to build and validate a whole-brain, domain-general model of brain connectivity changes following TMS, based on physical models of the current distribution at the cortex. PUBLIC HEALTH RELEVANCE: This work is relevant to public health because it will provide direct evidence that brain connectivity changes following neuromodulatory TMS vary as a function of the current density at the cortex, which can be used to predict psychiatric symptom change following neuromodulatory TMS.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Able to give their consent

Right-handed

Disqualifiers

Non-english speaking

Any significant medical problems

Current or past Axis I psychiatric disorder(s),

Active or history of active suicidal ideation

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intermittent Theta Burst Stimulation

    Device

    iTBS parameters. A series of 20, 10 s trains will be presented over the course of the \~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz).

  • Continuous Theta Burst Stimulation

    Device

    cTBS parameters. A single 600 pulse cTBS train will be delivered during each stimulation session. The train will consist of 50 Hz bursts, repeated at intervals of 200 ms (5 Hz) for 40 sec.

Treatment groups

200 Participants
are divided into 2 treatment groups
Group A: Intermittent Theta Burst StimulationExperimental treatment 1 intervention
Group B: Continuous Theta Burst StimulationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Resting state - dose 1

Investigators will measure resting state functional connectivity 24 hours after first dose of continuous or intermittent theta burst stimulation.

Time frame
24 hours
2

Resting state - dose 2

Investigators will measure resting state functional connectivity 24 hours after second dose of continuous or intermittent theta burst stimulation.

Time frame
24 hours
3

Resting state - dose 3

Investigators will measure resting state functional connectivity 24 hours after third dose of continuous or intermittent theta burst stimulation.

Time frame
24 hours
4

Working memory - dose 1

Investigators will measure reaction time during the Sternberg Working memory paradigm 24 hours after first dose of continuous or intermittent theta burst stimulation.

Time frame
24 hours

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nicholas Balderston, PhD

Lead sponsor

University of Pennsylvania

Sponsor institution

Source ClinicalTrials.gov
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