The purpose of this research is to identify differences in brain activity during sleep between health individuals and individuals with schizophrenia, schizophreniform, or schizoaffective disorder. This study will also investigate whether tones played during deep sleep can enhance specific features of sleep and whether enhancing such features is related to an improvement in cognitive performance.
ages 18-40 years
current DSM-IV defined diagnosis of schizophrenia, schizophreniform or schizoaffective disorder, not drug-induced, with no previously reported psychotic episode
duration of ≤5 years from beginning of psychosis, defined by report of symptoms and/or history of treatment according to clinical guidelines employed in our University of Pittsburgh Medical Center (UPMC) psychoses clinics in Pittsburgh
lifetime exposure to antipsychotic medications ≤5 years
DSM-IV intellectual disability
significant head injury
medical illness affecting brain function or structure
pregnancy or postpartum (<6 weeks after delivery or miscarriage)
Fabio Ferrarelli
Lead sponsor
University of Pittsburgh
Sponsor institution
National Institute of Mental Health (NIMH)
Collaborator