About this trial
In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Parameters such as the thickness of the choroid layer, which plays a crucial role in maintaining normal eye function, the dimensions of the foveal avascular zone (FAZ) supplied by this layer, and retinal vascular networks can be measured using non-invasive methods. OCTA (Optical Coherence Tomography Angiography) is an imaging tool that enables the non-invasive assessment of retinal microvascular densities and the measurement of the foveal avascular zone's dimensions. Studies conducted to date indicate that retinal capillary vessels and the dimensions of the foveal avascular zone are affected in rheumatological diseases, especially associated with systemic inflammation. This study aims to compare retinal capillary vessel density and foveal avascular zone dimensions in patients with psoriatic arthritis against those in a healthy population and in patients with psoriasis who do not have psoriatic arthritis, utilizing the non-invasive method of optical coherence tomography angiography.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Volunteers diagnosed with psoriatic arthritis according to CASPAR criteria
Volunteers diagnosed with psoriasis by a specialist dermatologist
Hospital staff or patient companions with no chronic illnesses
Disqualifiers
Diabetes mellitus
Cancer
Pregnancy or lactation
Chronic renal failure
Trial population
The study population consists of volunteers from among patients with psoriatic arthritis who are being followed at the study center's rheumatology clinic. The patient control group comprises volunteers diagnosed with psoriasis by a specialist dermatologist. Participants in the healthy control group are healthcare workers or patient companions matched for age and gender with the patient group and the patient control group.
Trial design
Case-control
Prospective
Treatments tested in this trial
OCTA-SCP
Diagnostic testVessel density of retinal superficial capillary plexus
OCTA-DCP
Diagnostic testVessel density of retinal deep capillary plexus
OCTA-RPC
Diagnostic testVessel density of retinal prepapillary capillaries
OCTA-FAZ
Diagnostic testFAZ essessment parameters
Treatment groups
Trial outcomes
Primary outcomes
Retinal SCP, VD
Vessel density of retinal superficial capillary plexus
Retinal DCP, VD
Vessel density of retinal deep capillary plexus
Retinal RCP, VD
Vessel density of retinal prepapillary capillaries
FAZ parameters
Foveal avasculary assessment parameters
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Bursa Yuksek Ihtisas Training and Research Hospital
Lead sponsor
Saglik Bilimleri Universitesi
Sponsor institution