Retinal Capillary Vessel Density and Foveal Avascular Zone Size in Patients With Psoriatic Arthritis: A Case-Control Study.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorBursa Yuksek Ihtisas Training and Research Hospital

About this trial

In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Parameters such as the thickness of the choroid layer, which plays a crucial role in maintaining normal eye function, the dimensions of the foveal avascular zone (FAZ) supplied by this layer, and retinal vascular networks can be measured using non-invasive methods. OCTA (Optical Coherence Tomography Angiography) is an imaging tool that enables the non-invasive assessment of retinal microvascular densities and the measurement of the foveal avascular zone's dimensions. Studies conducted to date indicate that retinal capillary vessels and the dimensions of the foveal avascular zone are affected in rheumatological diseases, especially associated with systemic inflammation. This study aims to compare retinal capillary vessel density and foveal avascular zone dimensions in patients with psoriatic arthritis against those in a healthy population and in patients with psoriasis who do not have psoriatic arthritis, utilizing the non-invasive method of optical coherence tomography angiography.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Volunteers diagnosed with psoriatic arthritis according to CASPAR criteria

Volunteers diagnosed with psoriasis by a specialist dermatologist

Hospital staff or patient companions with no chronic illnesses

Disqualifiers

Diabetes mellitus

Cancer

Pregnancy or lactation

Chronic renal failure

Trial population

The study population consists of volunteers from among patients with psoriatic arthritis who are being followed at the study center's rheumatology clinic. The patient control group comprises volunteers diagnosed with psoriasis by a specialist dermatologist. Participants in the healthy control group are healthcare workers or patient companions matched for age and gender with the patient group and the patient control group.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • OCTA-SCP

    Diagnostic test

    Vessel density of retinal superficial capillary plexus

  • OCTA-DCP

    Diagnostic test

    Vessel density of retinal deep capillary plexus

  • OCTA-RPC

    Diagnostic test

    Vessel density of retinal prepapillary capillaries

  • OCTA-FAZ

    Diagnostic test

    FAZ essessment parameters

Treatment groups

135 Participants
are divided into 3 treatment groups
Group A: Psoriatic arthritis4 interventions
Group B: Psoriasis4 interventions
Group C: Healthy controls4 interventions

Trial outcomes

Primary outcomes

1

Retinal SCP, VD

Vessel density of retinal superficial capillary plexus

Time frame
1 day
2

Retinal DCP, VD

Vessel density of retinal deep capillary plexus

Time frame
1 day
3

Retinal RCP, VD

Vessel density of retinal prepapillary capillaries

Time frame
1 day
4

FAZ parameters

Foveal avasculary assessment parameters

Time frame
1 day

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Bursa Yuksek Ihtisas Training and Research Hospital

Lead sponsor

Saglik Bilimleri Universitesi

Sponsor institution