Health TrialsbyHealthPanel

Retinal Neurovascular Coupling in Patients Previously Infected With COVID-19

ConditionsCOVID-19Post-COVID-19 Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMedical University of Vienna

About this trial

The Study objective is to measure retinal neurovascular coupling and blood flow parameters in patients previously infected with COVID-19, long COVID-19 and healthy age- and sex- matched control subjects

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Men and women aged over 18 years

Non-smokers

Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant

No previous history of COVID-19 infection

Disqualifiers

Symptoms of a clinically relevant illness in the 3 weeks before the first study day

Presence or history of a severe medical condition as judged by the clinical investigator

Participation in a clinical trial in the 3 weeks preceding the study

Blood donation during the previous three weeks

Trial population

A total of 90 subjects will be included: 30 subjects previously infected with COVID-19 30 subjects with long COVID-19 30 age-and sex- matched subjects with no history of COVID-19 infection

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

  • Dynamic Vessel Analyzer (DVA)

    Device

    Retinal neurovascular coupling, Retinal vessel diameters and Retinal oxygen saturation will be assessed using the DVA

  • Fourier domain optical coherence tomography (FDOCT)

    Device

    Retinal blood velocities and Retinal blood flow will be assessed using the FDOCT

  • Optical coherence tomography (OCT)

    Device

    Retinal nerve fiber layer thickness, Central retinal thickness and Retinal vessel density will be assessed using the OCT

  • Laser Speckle Flowgraphy (LSFG)

    Device

    Normalized blur and Relative flow volume will be assessed using the LSFG

  • Proteomics and Metabolites in Plasma, tear fluid and finger sweat

    Diagnostic test

    Proteomics and Metabolites in Plasma, tear fluid and finger sweat will be assessed using a Blooddraw, filter paper and Schirmer-test

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: subjects previously infected with COVID-195 interventions
Group B: subjects with long COVID-195 interventions
Group C: healthy age-and sex- matched control subjects with no history of COVID-19 infection5 interventions

Trial outcomes

Primary outcomes

1

Retinal neurovascular coupling

Retinal neurovascular coupling will be assessed using the DVA

Time frame
Day 0

Secondary outcomes

1

Retinal vessel diameters

Retinal vessel diameters will be assessed using the DVA

Time frame
Day 0
2

Retinal oxygen saturation

Retinal oxygen saturation will be assessed using the DVA

Time frame
Day 0
3

Retinal blood velocities

Retinal blood velocities will be assessed using FDOCT

Time frame
Day 0
4

Retinal blood flow

Retinal blood flow will be assessed using FDOCT

Time frame
Day 0

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medical University of Vienna

Lead sponsor

Source ClinicalTrials.gov
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