About this trial
Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary endpoint to estimate prevalence and incidence of pNCDs.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18 -100 years
Male or female patients undergoing elective surgery expected to last at least 60 min, screened at the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany
Written informed consent to participate after having been properly instructed
Disqualifiers
Lacking willingness to take part in the study, or to have relevant study data collected, saved and analyzed for the purpose of the study
Accommodation in an institution due to an official or judicial order
Insufficient knowledge of German language
Members of the hospital staff
Trial population
Male and female patients undergoing surgery, screened at the Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Neurocognitive Disorder (NCD)
Mild / major neurocognitive disorder 3 (mild / major NCD 'Postoperative cognitive dysfunction (POCD)') and 12 months (mild / major NCD) postoperatively.
Postoperative cognitive dysfunction (POCD)
Postoperative cognitive dysfunction (POCD) is defined as relevant change in postoperative cognitive performance compared to baseline (preoperative) cognitive performance.
Secondary outcomes
Suspected neurocognitive disorder due to MiniCog
The MiniCog is used for cognitive screening. A cut-off value of \<3 points is interpreted possible mild / major NCD. The Mini-Cog consists of a sub-test for word memory skills and a clock drawing test.
Suspected dementia from MOCA
The Montreal Cognitive Assessment (MOCA) with cut-offs according to normative age-adjusted values is used as dementia screening. The MOCA consists of 13 items, which are rated on a scale from 0 to 30 points.
Neurocognitive Disorder (NCD)
Mild / major neurocognitive disorder (mild / major NCD) 60months postoperatively.
Suspected postoperative neurocognitive disorder (mild / major NCD 'POCD')
The non-computerized neuropsychological trail making test is used as an indicator screening test for relevant cognitive changes after the operation. The cut-off is an increase in TMT-B test performance of\> 55 seconds three and / or 12 months after the operation compared to the baseline value.
Other outcomes
Demographics
Demographics are measured by demographic data.
Neurological diseases
Neurological diseases are taken from the hospital record
Waist circumference
Waist circumference is measured in cm.
Hip circumfernece
Hip circumference is measured in cm.
Sponsors and contacts
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