This multicenter retrospective real-world data study will evaluate the burden of respiratory tract infection (RTI)-related hospitalizations in up to 10 Dutch hospitals between 2018 and 2026.
The study aims to quantify:
* Hospitalization rates * Healthcare resource utilization (LOS, ICU admissions, readmissions) * Clinical outcomes (including mortality) * Direct healthcare costs * Pathogen-specific burden (e.g., RSV, influenza, SARS-CoV-2) Using linked hospital, laboratory, and administrative data, outcomes will be analyzed by age group, comorbidities, pathogen, and respiratory season. The expected cohort size is approximately 60,000-70,000 patients.
The results will provide evidence to support Dutch public health policy, including RSV immunization strategies, healthcare capacity planning, and antimicrobial stewardship.
All patients with any care activity during a hospitalisation registered under any primary or secondary RTI ICD-10 code; hospital admission beginning within April 2018 - July 2026.
Patients who have formally objected to the use of their hospital data for scientific research.
Patients of all ages (paediatric and adult) admitted to Dutch hospitals with a primary or secondary ICD-10 diagnosis of respiratory tract infection (RTI) during the period April 2018 through July 2026. Patients are identified through routinely collected administrative data (DBC) from up to 10 participating Dutch hospitals, representing a mix of academic, large peripheral, and smaller peripheral centres.
Cohort
Retrospective
Respiratory tract infection hospitalisation
Other interventionHospitalisation with a primary or secondary ICD-10 diagnosis of respiratory tract infection (RTI), including infections caused by RSV, influenza, SARS-CoV-2, and other viral or bacterial pathogens, identified through routine administrative and laboratory data.
Number of RTI-related hospitalisations
hospitalisation registered under any primary or secondary RTI ICD-10 code
ICU admission rate
ICU admissions under any primary or secondary RTI ICD-10 code per season
ICU length of stay
length measured in days per patient per season
In-hospital all-cause mortality rate;
Microbiological testing rate
Number of hospitalised RTI patients with a microbiology test
Healthcare resource utilization (HCRU) 30 days post-admission
Number of outpatient clinics visits per patient until 30 days post RTI related discharge
Direct healthcare costs per RTI-related hospitalisation
Pathogen-specific hospitalizations
pathogen specific hospitalization rate (number of patients per year)
This trial is not recruiting at the moment. You can still explore other options:
