Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorUniversity of Colorado, Denver
About this trial
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity [FEV1/FVC] <0.7)
Age >= 40 years
Disqualifiers
Exacerbation of COPD in the 3 months prior to enrollment
Change in COPD therapy in the 3 weeks prior to enrollment
Requirement of >6 LPM supplemental oxygen at rest
Requirement of >10 LPM supplemental oxygen with exertion
Trial design
Design model
Single group
Treatments tested in this trial
Exercise training
BehavioralExercise training will include moderate-intensity interval training 3x/week.
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: COPDExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Right ventricular contractility measured by transthoracic echocardiography
Global longitudinal strain, measured in absolute percent
Time frame
Up to 1 hourSecondary outcomes
1
Right ventricular contractility measured by conductance catheter
Maximum rate of pressure change, dP/dtmax in mmHg/sec
Time frame
Up to 1 hour2
Right ventricular systolic function measured by transthoracic echocardiography
Fractional area change on transthoracic echocardiography, measured in percent
Time frame
Up to 1 hour3
Right ventricular systolic function measured by transthoracic echocardiography
Tricuspid annular plane systolic excursion on transthoracic echocardiography, measured in centimeters
Time frame
Up to 1 hour4
Exercise training feasibility
Proportion of exercise training sessions completed
Time frame
4 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Colorado, Denver
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov