Risk Factors Affecting Growth in Thalassemic Children at AUCH
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-18
SponsorAssiut University
About this trial
Thalassemia major is a hereditary hemoglobinopathy characterized by ineffective erythropoiesis and severe anemia, necessitating lifelong blood transfusions(1,2). Regular transfusions lead to iron overload, a primary driver of growth retardation in affected children. Iron accumulation in tissues like the pituitary and liver disrupts growth hormone secretion and insulin-like growth factor-1 production.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged 1 to 18 years diagnosed with β-thalassemia major based on hemoglobin electrophoresis or high-performance liquid chromatography (HPLC).
Receiving regular blood transfusions as part of standard management at AUCH.
Attending the hematology unit for at least one year prior to enrollment.
Disqualifiers
• Children with other types of thalassemia.
Presence of congenital diseases, chronic illnesses other than thalassemia (e.g., malignancy, tuberculosis, chronic hepatitis, congenital heart disease, chronic renal failure, epilepsy, diabetes mellitus), or primary endocrinopathies.
Patients with other causes of short stature, such as hereditary bone dysplasia or systemic disorders.
Trial population
All children with transfusion-dependent beta-thalassemia major attending the AUCH Hematology Unit will be screened for eligibility.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Non-interventional assessment of growth and risk factors in thalassemic children
Other interventionNo therapeutic intervention is applied. The study involves only observational assessment of clinical history, anthropometric measurements, laboratory investigations, and growth parameters in thalassemic children. This distinguishes it from interventional studies.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Growth parameters: Z-scores for height-for-age, weight-for-age, BMI-for-age
Time frame
1 yearLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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