Risk Factors and Severity of Bronchiolitis in Hospitalized Children at Assiut University Hospital
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-24
SponsorAssiut University
About this trial
The purpose of this observational study is to identify the risk factors that make bronchiolitis more severe in infants and toddlers. Bronchiolitis is a common viral lung infection that causes inflammation and airway obstruction, often leading to breathing difficulties and hospitalization in young children.
Researchers will observe approximately 65 children, aged 1 to 24 months, who are admitted to Assiut University Hospital for acute bronchiolitis. Because this is an observational study, participants will receive standard medical care, and no experimental treatments will be tested.
During the hospital stay, researchers will collect information through parent questionnaires and standard medical records. The research team will gather data on:
* Family, social, and environmental factors, such as infant feeding practices, premature birth, and exposure to passive smoking. * The child's clinical symptoms and overall severity of illness upon arrival at the hospital. * Routine test results and the types of supportive care the child needs, such as extra oxygen or feeding assistance. * The total length of the hospital stay and whether the child requires intensive care (ICU) admission.
By identifying which factors are most closely linked to severe illness, the study aims to help doctors better predict the course of the disease early on, evaluate adherence to treatment guidelines, and ultimately reduce the health burden of bronchiolitis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged 1-24 months presenting with acute bronchiolitis, defined per AAP 2014 criteria: preceding upper respiratory infection, wheezing, tachypnoea (>60 breaths/min <2 months, >50 <12 months, >40 >12 months), and signs of respiratory distress (nasal flaring, grunting, retractions).
Confirmed clinical diagnosis by a pediatric pulmonologist.
Disqualifiers
Known congenital heart disease, chronic lung disease (e.g., bronchopulmonary dysplasia), immunodeficiency, or neuromuscular disorders.
Recurrent wheezing suggesting asthma.
Gestational age <32 weeks without recovery or birth weight <1500g without catch-up growth.
Immunosuppression, recent (within 2 weeks) systemic steroids or antibiotics.
Trial population
The study population consists of hospitalized children aged 1 to 24 months presenting with acute bronchiolitis at Assiut University Hospital. Patients are eligible if they have a clinical diagnosis confirmed by a pediatric pulmonologist according to the AAP 2014 criteria, presenting with a preceding upper respiratory infection, wheezing, tachypnea, and signs of respiratory distress. The population strictly excludes children with underlying comorbidities that might independently affect respiratory severity, including known congenital heart disease, chronic lung disease, immunodeficiencies, and neuromuscular disorders. Furthermore, patients with a history of recurrent wheezing, extreme prematurity (gestational age \<32 weeks without recovery) or low birth weight (\<1500g without catch-up growth), and those who have received systemic steroids or antibiotics within the past two weeks are excluded from the study cohort.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
65 Participants
are grouped into 1 trial groupGroup A: Hospitalized Children with Acute Bronchiolitis
Trial outcomes
Primary outcomes
1
Bronchiolitis Clinical Severity Score
Disease severity will be assessed upon hospital presentation using a standardized clinical scoring tool. The tool yields a single total score based on the clinical evaluation of respiratory parameters. A total score of 8 or higher categorizes the participant as having severe bronchiolitis.
Time frame
At hospital admission (Day 0)Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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