Risk Factors of Mortality in Neonatal Pneumonia

Methods

Our study will be retrospective cross sectional study,and the cases will be collected from archive of neonatology unit of assiut university children hospital as well as prospective single group cohort study and will be conducted in neonatalogy unit in Children Hospital in Assiut University for one year duration. Newborn babies aged since birth to ≤ 28 days who have been diagnosed with pneumonia will be included.

History

Full history will be taken from all patient with emphasis on the following : Maternal history: Demographic history 1- Maternal age 3-- socioeconomic state Medical conditions: Any infection during pregnancy. Events during pregnancy (e.g. PROM, pre-eclampsia, Gestationale diabetes, …). Autoimmune diseases. Any comorbid disease that affect immunity (DM, CKD, etc. …). Surgical history: Any operation conducted during pregnancy. Blood transfusion (during pregnancy). Obstetric history: Mode of labor ( Cesarean / Vaginal). Maternal fever Parity. Neonatal history: Time of diagnosis (prenatal- at birth- first day- second day- … - 30th day) Signs of hypoxia at birth (cyanosis- respiratory distress- ……) Tachypnea Fever Admission in NICU

Examination

General and local examination will be done to all patient with emphasis on the following: Oxygen saturation. Temperature. Centeral and Peripheral Cyanosis. Congenital anomalies. Chest examination: Inspection: Deformity of thorax. / Shape of the thorax (Deformity, Movement,…) Signs of distress (tachypnea, nasal flaring, Lower chest indrawing). Respiratory rate Palpation Percution Auscultation: Breathing sounds. Decreased air entry Rales or ronchi Crepitation

Investigations

All patients will be subjectd to the following investigations: Complete blood count (CBC) for neonate. Chest X-ray. Blood culture. C- reactive protein. ESR Serum Na, K. Kidney Function Test (KFT) Liver Function Test (LFT) Some of cases will be subjectd to the following investigations according to the clinical status : CT - Chest Echocardiograpgy Bronchoalveolar lavage Neonatal Pneumonia Mortality will be considered as death occurring in pneumonic neonate during their first month of life while hospitalization.