Risk Markers of Arterial Aging. The Paris Prospective Study III-2

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age60-95
SponsorInstitut National de la Santé Et de la Recherche Médicale, France

About this trial

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Being enrolled in PPS3 and having signed an informed consent for PPS3-2

Disqualifiers

Institutionalized participants

Participants under guardianship

Participants under judicial safeguard measure

Trial population

Men and women aged 60 to 95 years who are participants of the PPS3 study and have accepted to undergo a second physical examination and answer to health questionnaires in primary care health centre in Paris that is subsidized by the French Health Insurance System.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • high-precision carotid echo-tracking

    Other intervention

    evaluation of vascular aging parameters and baroreflex sensitivity

Treatment groups

7,500 Participants
are divided into 1 treatment group
Group A: Level of vascular aging1 intervention

Trial outcomes

Primary outcomes

1

carotid diameter

high precision carotid echo tracking diameter in mm

Time frame
by 2027
2

intima media thickness

high precision echo tracking intima media thickness of the common carotid artery in mm

Time frame
by 2027
3

carotid plaques

high precision carotid echo tracking carotid plaques

Time frame
by 2027
4

wall cross sectional area

high precision carotid echo tracking carotid wall cross sectional area, mm2

Time frame
by 2027

Secondary outcomes

1

brachial artery diameter

ultra high frequency ultrasound radial artery diameter in mm

Time frame
by 2027
2

thickness of the intima media of the radial artery

ultra high frequency ultrasound radial artery intima media thickness in mm

Time frame
by 2027
3

arterial plaques

ultra high frequency ultrasound radial artery plaques

Time frame
by 2027
4

wall cross sectional area of the radial artery

ultra high frequency ultrasound radial artery wall cross sectional area, mm2

Time frame
by 2027

Other outcomes

Sponsors and contacts

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