Role and Diagnostic Yield of Upper Endoscopy in Children With Chronic Abdominal Pain
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0-18
SponsorAssiut University
About this trial
Chronic abdominal pain is a common problem in children and may be caused by functional or organic gastrointestinal disorders. While many children have no identifiable structural disease, some may have conditions that can be detected by upper gastrointestinal endoscopy. This study aims to evaluate the role and diagnostic outcome of upper gastrointestinal endoscopy in children presenting with chronic abdominal pain at Assiut University Children Hospital.
Children aged 18 years or younger who have had abdominal pain for at least three months and who undergo upper gastrointestinal endoscopy as part of their routine medical care will be included. Clinical symptoms, alarm features, endoscopic findings, and biopsy results will be analyzed to determine how often endoscopy identifies an organic cause of pain. The results of this study may help guide the appropriate use of endoscopy in the evaluation of chronic abdominal pain in children.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged ≤18 years.
Suffering from chronic abdominal pain lasting ≥3 months.
Undergoing upper gastrointestinal endoscopy at Assiut University Children Hospital.
Disqualifiers
Pre-existing chronic diseases that may alter symptoms, such as inflammatory bowel disease or liver disease (unless these are diagnosed as a result of the study).
Patients with "alarm symptoms" that require urgent, immediate intervention, such as active gastrointestinal bleeding.
Patients or guardians who refuse to participate.
Trial population
The population consists of pediatric patients (up to 18 years old) presenting to the pediatric gastroenterology and hepatology unit of Assiut University Children Hospital with a primary complaint of chronic abdominal pain lasting at least 3 months. The estimated sample size is approximately 130 pediatric patients.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Upper Gastrointestinal Endoscopy
Diagnostic testUpper gastrointestinal endoscopy (esophagogastroduodenoscopy) is performed as part of standard clinical care to evaluate children with chronic abdominal pain. The procedure allows direct visualization of the esophagus, stomach, and duodenum, with biopsy sampling when clinically indicated for histopathological examination. The procedure is not assigned by the study protocol but is analyzed observationally.
Treatment groups
130 Participants
are divided into 1 treatment groupGroup A: Children with chronic abdominal pain1 intervention
Trial outcomes
Primary outcomes
1
Diagnostic Yield of Upper Gastrointestinal Endoscopy
Diagnostic yield is defined as the proportion of children with chronic abdominal pain who have abnormal findings detected by upper gastrointestinal endoscopy and/or histopathological examination of biopsy specimens.
Time frame
At the time of upper gastrointestinal endoscopy during the study period (January 2026-December 2026)Secondary outcomes
1
Pattern of Endoscopic and Histopathological Findings
Assessment of the types and frequencies of abnormal endoscopic findings (esophageal, gastric, and duodenal) and corresponding histopathological diagnoses among children with chronic abdominal pain.
Time frame
At the time of upper gastrointestinal endoscopy during the study period (January 2026-December 2026)2
Association Between Alarm Features and Abnormal Endoscopic Findings
Evaluation of the relationship between the presence of alarm symptoms (such as weight loss, gastrointestinal bleeding, persistent vomiting, poor growth, or chronic diarrhea) and abnormal upper gastrointestinal endoscopic or histopathological findings.
Time frame
At the time of upper gastrointestinal endoscopy during the study period (January 2026-December 2026)3
Severity of Abdominal Pain in Relation to Endoscopic Findings
Correlation between abdominal pain severity assessed using a standardized pain score and the presence or absence of abnormal endoscopic or histopathological findings.
Time frame
At the time of clinical assessment and upper gastrointestinal endoscopy during the study period (January 2026-December 2026)Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: