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Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease

ConditionWilson Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age6-65
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

About this trial

The investigators aimed to identify factors associated with symptoms and features of Wilson disease from a large cohort during long-term follow-up

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

genetically diagnosed patients with wilson disease

Disqualifiers

Deny follow-up

Trial population

Patients with wilson disease

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • low copper diet

    Dietary supplement

    All patients with wilson disease should receive low copper diet

Treatment groups

1,000 Participants
are divided into 1 treatment group
Group A: Wilson's disease cohort1 intervention

Trial outcomes

Primary outcomes

1

Serum ceruloplasmin

Serum ceruloplasmin levels were collected among patients with wilson disease. After confirming a non-Gaussian distribution, the reference range of serum ceruloplasmin level was determined.

Time frame
From 2004 through 2030
2

Urinary Copper Excretion

The measurement of 24-hour urine copper excretions were collected and measured.

Time frame
From 2004 through 2030
3

Kayser-Fleischer Rings

The presence of Kayser-Fleischer Rings among patients with wilson disease were confirmed via slit lamp.

Time frame
From 2004 through 2030
4

Brain Magnetic Resonance Imaging

Brain Magnetic Resonance Imaging of all patients were collected and analyzed.

Time frame
From 2004 through 2030

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Second Affiliated Hospital, School of Medicine, Zhejiang University

Lead sponsor

Source ClinicalTrials.gov
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