Role of Corneal Nerves in Dry Eye Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorDaniela Nosch
About this trial
This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Group with DED: Diagnosis of DED based on the TFOS DEWS II report
Group without DED: No diagnosis of DED
Disqualifiers
Systemic disease that may affect ocular health and innervation
injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
regular application of systemic or ocular medication known to affect the tear film except from DED medications
eye drops or makeup on the day of measurement.
Trial population
healthy adults as well as adult with dry eye disease
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
140 Participants
are grouped into 2 trial groupsGroup A: Control
Group B: DED group
Trial outcomes
Primary outcomes
1
Differences of corneal nerve function and morphology in relation with DED signs
Correlation coefficient between corneal sensitivity and corneal nerve morphology, and variables related to tear film stability and corneal surface homeostasis.
Time frame
within one weekSecondary outcomes
1
Differences of corneal nerve function and morphology in relation with DED symptoms
Correlation coefficient between corneal sensitivity, corneal nerve morphology, and the severity of dry eye symptoms.
Time frame
within one weekSponsors and contacts
Click on the lead sponsor to view all of their trials.
Daniela Nosch
Lead sponsor
University of Applied Sciences and Arts Northwestern Switzerland
Sponsor institution
Source ClinicalTrials.gov