Role of Elastic Power in Acute Respiratory Distress Syndrome
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorHospital El Cruce
About this trial
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces. VILI results from the interaction between lung structure and mechanical ventilation factors, such as tidal volume, plateau pressure, driving pressure, inspiratory flow, respiratory rate, and PEEP. Intrinsic factors like lung heterogeneity further increase the risk.
Elastic power (EP), a key component, is linked to repetitive alveolar stretching and disease progression.
Study Objectives:
Examine the correlation between elastic power and pulmonary hyperinflation. Compare EP's sensitivity and specificity with other overdistension markers like driving pressure, plateau pressure, upper inflection point, and compliance.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
History of emphysema, asthma, or pneumothorax.
Severe instability at the time of the study preventing the PEEP titration maneuver, defined by at least one of the following indicators: SaO₂ ≤ 90%, shock requiring >0.5 γ/kg/min of norepinephrine, complex arrhythmia, myocardial ischemia, or intracranial hypertension refractory to initial treatment.
Patients with do-not-resuscitate orders and pregnant women.
Trial population
Adult patients (≥18 years) with moderate-to-severe acute respiratory distress syndrome (ARDS) included in UCI.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Comparison between pulmonary hyperinflation and pulmonary elastic power
Time frame
1 hourLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: