Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-65
SponsorNoor-Ul-Ain
About this trial
To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
1. Age Limit : 25 years to 65 years
Disqualifiers
1. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of pulmonary bulla 5. Patients having history of pneumothora
Trial design
Design model
Parallel
Treatments tested in this trial
Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries
Other interventionProtective lung ventilation methods with positive end-expiratory pressure help in prevention of atelectasis and improvement of intraoperative ventilator parameters e.g low driving pressure and improved dynamic compliance resulting in better oxygenation of lungs ere will be three groups in this study. Individualized positive end-expiratory pressure with recruitment maneuver and fixed positive end-expiratory pressure will be interventional groups. They will be compared with conventional ventilation group in which no additional positive end-expiratory pressure will be applied. The effects on respiratory parameters and oxygenation of patients will be compared for each group. This study will determine which method of positive end-expiratory pressure is superior and how it differs from conventional ventilation for prevention of atelectasis induced by pneumoperitonium and improvement of respiratory mechanical parameters and oxygenation in Mechanical ventilation during laparoscopic surgeries.
Treatment groups
75 Participants
are divided into 3 treatment groupsGroup A: 5cm of water Positive End-expiratory Pressure will be applied after induction of general anesthesiaPlacebo comparator 1 intervention
Group B: Individualized PEEP with recruitment maneuver guided by driving pressure measurementExperimental treatment 1 intervention
Group C: Conventional ventilationNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Driving pressure
Driving pressure is defined as airway plateau pressure minus positive end-expiratory pressure and reflects the degree of ventilator induced trauma. Airway plateau pressure and positive end-expiratory values will be taken from ventilator monitor.
Time frame
10 minutes after induction of general anesthesia, 10 minutes after pneumoperitonium creation and 10 minutes before extubation of patient2
Dynamic compliance of lungs
Dynamic compliance is change in lung volume by the change in pressure in the presence of airflow and is calculated by dividing tidal volume of a breath with difference between peak pressure of airway and positive end-expiratory pressure. Tidal volume, peak airway pressure and positive end-expiratory pressure will be noted from ventilator machine monitor.
Time frame
10 minutes after induction of general anesthesia, 10 minutes after pneumoperitonium creation and 10 minutes before extubation of patient3
Oxygenation Index
Oxygenation index is calculated by following formula: OI = Mean Airway Pressure × FiO2 × 100 ÷ PaO2 FiO2 (fractional inspiration of oxygen) and PaO2 (partial pressure of oxygen) will be recorded from arterial blood gas analysis.
Time frame
10 minutes after induction of general anesthesia and 10 minutes before extubation of patientSponsors and contacts
Click on the lead sponsor to view all of their trials.
Noor-Ul-Ain
Lead sponsor
Combined Military Hospital Bahawalpur
Sponsor institution
Source ClinicalTrials.gov
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