Role of Low Dose Injectable Progesterone in Triggering Ovulation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-35
SponsorThe General Authority for Teaching Hospitals and Institutes
About this trial
The aim of this study is to evaluate the role of low dose injectable progesterone in triggering ovulation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age from 20 to 35 years.
Infertile women.
Basal follicle-stimulating hormone (FSH) level <10 mIU/ml.
Disqualifiers
Poor ovarian reserve.
Immunological disease.
Endometriosis.
Uterine abnormality.
Trial design
Design model
Parallel
Treatments tested in this trial
Progesterone
DrugWomen will receive low dose progesterone 5 mg intramuscularly as a study group. (Letrozole 2.5 mg/day will be given from cycle day 3 onwards for only 5 days).
Placebo
DrugWomen will receive placebo as a control group. (Placebo 2.5 mg/day will be given from cycle day 3 onwards for only 5 days).
Treatment groups
120 Participants
are divided into 2 treatment groupsGroup A: Progesterone groupExperimental treatment 1 intervention
Group B: Control groupPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Incidence of ovulation rates
Incidence of ovulation rates will be recorded.
Time frame
10-12 days of the menstrual cycleSecondary outcomes
1
Follicle stimulating hormone (FSH)levels
Follicle stimulating hormone (FSH) will be measured on day 3, day 8-10 and day 10-12 of the menstrual cycle, as well as the day of trigger and oocyte retrieval.
Time frame
10-12 days of the menstrual cycle2
Luteinizing hormone (LH)levels
Luteinizing hormone (LH) will be measured on day 3, day 8-10 and day 10-12 of the menstrual cycle, as well as the day of trigger and oocyte retrieval).
Time frame
10-12 days of the menstrual cycle3
Estradiol (E2) levels
Estradiol (E2) will be measured on day 3, day 8-10 and day 10-12 of the menstrual cycle, as well as the day of trigger and oocyte retrieval.
Time frame
10-12 days of the menstrual cycle4
Progesterone levels
Progesterone levels will be measured on day 3, day 8-10 and day 10-12 of the menstrual cycle, as well as the day of trigger and oocyte retrieval.
Time frame
10-12 days of the menstrual cycleSponsors and contacts
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Source ClinicalTrials.gov