Role of Peripheral Vision in Scene Perception (PERISCE)

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorUniversity Hospital, Grenoble

About this trial

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

between 18 and 80 years old

stable bilateral primary open angle glaucoma (POAG)

visual acuity > 5/10 for distant vision for the eye tested

peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

Disqualifiers

ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Trial population

POAG patients and age-matched normally sighted controls

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Psychophysical evaluation

    Behavioral

    All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard.

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Primary open-angle glaucoma (POAG) group1 intervention
Group B: Age-matched normally sighted control group1 intervention

Trial outcomes

Primary outcomes

1

Psychophysical measure : Percentage of correct response

Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment

Time frame
Through study completion of 45 months
2

Psychophysical measure : Mean reaction time in milliseconds

Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment

Time frame
Through study completion of 45 months

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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