The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:
1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?
Participants will have blood drawn from them but will not be subjected to additional interventions.
Age 18 or older
Admitted to ICU with sepsis (Sepsis 3 Criteria)
SOFA score of at least 2 at time of enrollment
Patients on organ transplantation immunosuppression
Patients with preexisting leukopenia
Cancer patients receiving CAR-T therapy
Patients who are under 18 years of age or otherwise deemed pediatric
The study population includes adult patients admitted to the intensive care unit with sepsis with a SOFA score of at least 2. Sepsis is defined by the Sepsis 3 Criteria.
Cohort
Prospective
RNA and DNA Sequencing
GeneticDNA and RNA sequencing will be conducted on both control participants and patients with sepsis who are admitted to the ICU.
Immune Aging
Mortality (30-day)
Secondary Infection
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University of California, San Francisco
Lead sponsor
National Cancer Institute (NCI)
Collaborator
