Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.

ConditionChronic Coronary Syndrome

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-85

SponsorUniversity of Thessaly

About this trial

The aim of this study is to measure the levels of serum tryptase and correlate them with the severity of coronary artery disease in study population. In addition, it will evaluate the usability of tryptase levels as a prognostic biomarker for future cardiovascular events.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Male and female subjects aged 18 - 85 years old.

Clinical symptoms of angina which are classified based on the Canadian Cardiovascular Score (CCS score)

Positive SPECT scan for myocardial ischemia

Disqualifiers

Acute Coronary Syndrome 4 weeks before the coronary catheterization

Percutaneous Coronary Angioplasty

Coronary Artery Bypass Graft

Active symptoms of allergy (asthma, urticaria)

Trial population

This is a multicentre study which take place at the military hospital 417 NIMTS, Athens and the Larissa University Hospital, Larissa. Participants from both locations are patients who are going to undergo percutaneous coronary intervention. These patients will enter the study after fulfiling the inclusion criteria.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants

are grouped into 2 trial groups

Group A: Coronary Artery Disease Group

Group B: Non-coronary Artery Disease Group

Trial outcomes

Primary outcomes

Serum tryptase levels as a biomarker in CCS

Correlation of tryptase levels with Coronary Artery Disease gravity

Time frame

Baseline

Secondary outcomes

Tryptase and major cardiovascular evens

Correlation of tryptase levels with possible major cardiovascular events (death, myocardial infarction)

Time frame

12 months after the completion of recruitment

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Thessaly

Lead sponsor

Source ClinicalTrials.gov

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