About this trial
This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients. To ensure a high level of clinical accuracy, the investigation specifically focuses on a cACB cohort where ultrasound confirmation ensures the catheter remains correctly positioned for a full 48 hours. Participants are assigned to groups using a 1:1 randomization protocol via computer-generated tables to eliminate selection bias. Clinical consistency is maintained by using identical pharmacological agents across both groups: 0.5% Heavy Bupivacaine for spinal anesthesia and 0.5% ropivacaine with 1:200,000 epinephrine for the nerve block itself. Furthermore, both groups adhere to a standardized multimodal analgesic schedule to control for external variables. In the cACB group, intravenous patient-controlled analgesia (IV PCA) serves as a designated rescue therapy should the catheter fail. The primary technical evaluation occurs 48 hours post-surgery, utilizing ultrasound to verify catheter placement and quantify pain levels. Beyond immediate recovery, the study evaluates long-term success through Patient-Reported Outcome Measures (PROMs) at a 12-week follow-up, focusing on functional restoration and the patient's overall quality of life. By isolating the variable of catheter stability, the research aims to provide a definitive comparison of whether the continuous delivery of local anesthetic offers a statistically significant clinical advantage over a single-dose administration in the context of modern orthopedic recovery protocols.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 40-80 yrs
Scheduled for unilateral total knee arthroplatsy
ASA I-III
BMI 18-35 kg/㎡
Disqualifiers
Allergy to local anesthetics
Infection at the block site
History of neuropathy or peripheral nerve disease
Coagulation disorders or use of anticoagulants (if discontinuation is not possible)
Trial design
Parallel
Treatments tested in this trial
Continuous ACB
Procedure/SurgeryAdductor canal block, a lower extremity nerve block technique for postoperative pain control, is performed under ultrasound guidance for patients undergoing total knee arthroplasty, and is carried out by inserting a catheter. The catheter is connected to a PCA pump following insertion, with a continuous infusion rate for two days post-surgery.
Single-shot ACB
Procedure/SurgeryAdductor canal block, a lower extremity nerve block technique for postoperative pain control, is performed under ultrasound guidance for patients undergoing total knee arthroplasty, and is carried out by a single-shot local anesthetic administration.
Treatment groups
Trial outcomes
Primary outcomes
postoperative pain score at rest (Area Under Curve, AUC)
48-hour postoperative pain score at rest (Area Under Curve, AUC) using NRS.
Locations
Sponsors and contacts
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