Safety and Efficacy of CLL1 CAR-T Followed by Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-78
SponsorDonghua Zhang

About this trial

This study aims to evaluate whether an innovative combination therapy (CLL1 CAR-T sequential allogeneic hematopoietic stem cell transplantation) is safe, feasible and effective for the treatment of relapsed/refractory acute myeloid leukemia (R/R AML).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients or their guardians understand and voluntarily sign the informed consent form, and are expected to complete the follow-up examinations and treatments as required by the study protocol.

Disqualifiers

History of other malignancies within 3 years prior to screening, except for adequately treated cervical carcinoma in situ, papillary thyroid carcinoma, basal cell or squamous cell skin carcinoma, locally treated prostate cancer after radical treatment, and ductal carcinoma in situ after radical treatment.

Trial design

Design model

Single group

Treatments tested in this trial

  • CLL1 CAR-T Cell Sequential Allogeneic Hematopoietic Stem Cell Transplantation

    Drug

    CLL1 CAR-T Cell Sequential Allogeneic Hematopoietic Stem Cell Transplantation

Treatment groups

18 Participants
are divided into 1 treatment group
Group A: Experimental:Experimental groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Overall survival

Time frame
1,3,6,12,18,24 months after treatment

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Donghua Zhang

Lead sponsor

Tongji Hospital

Sponsor institution

This trial is not recruiting at the moment. You can still explore other options: