Study objectives:
Primary objective:
1.To determine the histologic R0 resection rate of UEMR for type I gastric NETs measuring 5-9 mm.
Secondary objectives:
To evaluate:
1. En bloc resection rate 2. Immediate and delayed adverse events 3. Procedure time 4. Histologic quality of resection (deep and lateral margins) 5. Residual disease at resection scar on surveillance endoscopy oMetachronous gastric NETs during follow-up
Age ≥18 years
Fit for endoscopic therapy and sedation
Written informed consent
Endoscopically visible gastric neuroendocrine tumor
Size 5-9 mm (endoscopic estimation)
Clinical and/or histologic features consistent with type I gastric NET
No endoscopic features suggestive of deep invasion
Single group
Endoscopic mucosal resection under water
Procedure/Surgery* Standard diagnostic gastroscope * Minimal insufflation followed by complete deflation of the gastric lumen * Lumen filled with normal saline to achieve complete submersion of the lesion * Optional marking for flat or ill-defined lesions * Snare capture with a 1-2 mm margin under water * Resection using standardized electrosurgical settings * Defect management (clips or coagulation) at endoscopist discretion * Retrieval of intact specimen * Specimen orientation and pinning on cork for histopathologic assessment
• To determine the histologic R0 resection rate of UEMR for type I gastric NETs measuring 5-9 mm.
No recurrence after 3 months of procedure
Immediate and delayed adverse events
To check any possible adverse events post procedure
Procedure time
To calculate the exact time of procedure
Histologic quality of resection (deep and lateral margins)
To check the depth of invasion of the tumour
Click on the lead sponsor to view all of their trials.
