Saline Infusion Test in Hyponatremia

ConditionHyponatremia

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity Hospital, Akershus

About this trial

Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Plasma sodium 120-130 mmol/L

Effective osmolality (2 x plasma sodium + plasma glucose) < 275 milliosmol/L

Age > 18 years

Disqualifiers

Intensive care unit (ICU) admission

Adequate sodium correction rate: > 4 mmol/L last 24 hours

Primary polydipsia: urine osmolality < 100 mOsm/L

Hypertonic saline therapy

Trial population

Patients admitted to hospital with hyponatremia.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Isotonic saline infusion
Other intervention
Volume expansion with one liter of isotonic saline intravenously over two hours.

Treatment groups

100 Participants

are divided into 1 treatment group

Group A: Adult patients with hypoosmolar hyponatremia1 intervention

Trial outcomes

Primary outcomes

Copeptin plasma levels

Changes in copeptin levels in response to isotonic saline infusion

Time frame

240 minutes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Akershus

Lead sponsor

Hormone Laboratory, Aker University Hospital, Oslo, Norway

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: