Salivary Replication of BK Virus in Post-kidney Transplant

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

kidney transplant recipients

age ≥ 18 years

Disqualifiers

age < 18 years

absence of consent

Trial design

Design model

Single group

Treatments tested in this trial

  • Salivary self-collection

    Biological/Vaccine

    Salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Number of BK positive saliva and blood samples

Compare the positivity of the BK virus viral load between the saliva sample and the urine and blood samples

Time frame
12 months

Secondary outcomes

1

urinary BK virus concentration

Time frame
12 months
2

variation of BK virus genome

variation of BK virus genome in different samples

Time frame
12 months
3

Immunoglobin concentrations

Immunoglobin concentrations in different samples

Time frame
12 months

Other outcomes

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: