About this trial
BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
kidney transplant recipients
age ≥ 18 years
Disqualifiers
age < 18 years
absence of consent
Trial design
Single group
Treatments tested in this trial
Salivary self-collection
Biological/VaccineSalivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months
Treatment groups
Trial outcomes
Primary outcomes
Number of BK positive saliva and blood samples
Compare the positivity of the BK virus viral load between the saliva sample and the urine and blood samples
Secondary outcomes
urinary BK virus concentration
variation of BK virus genome
variation of BK virus genome in different samples
Immunoglobin concentrations
Immunoglobin concentrations in different samples
Sponsors and contacts
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